April 14

Health Benefits of Melatonin: Exploring Its Impact on Sleep, Stress, and Immunity

By Dr. Kelley S. Mulhern, MS, DC, MPH, CFMP

Melatonin is a hormone naturally produced by the body, primarily in the pineal gland, and plays a vital role in regulating sleep patterns. It assists in the synchronization of our sleep-wake cycles, also known as circadian rhythms, by signaling the body to fall asleep when it gets dark outside. Melatonin production typically increases during the evening hours and decreases in the morning, helping to maintain a healthy sleep schedule.

In addition to its primary role in sleep regulation, melatonin has been associated with a variety of other health benefits. It has been shown to provide support for the immune system, decrease inflammation, and potentially help protect against certain age-related disorders. The use of melatonin supplements has become increasingly popular in recent years, as people seek natural remedies for sleep disturbances and other health concerns.

Key Takeaways

  • Melatonin is a hormone responsible for regulating sleep patterns and supporting overall health.
  • Research suggests melatonin may offer a variety of health benefits beyond sleep, including immune support and protection against age-related disorders.
  • Supplements are available to assist with melatonin production, but natural sources and lifestyle changes can also help in managing sleep disturbances.
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Melatonin: The Sleep Hormone

Synthesis and Regulation

Melatonin, a hormone produced in your pineal gland, plays a crucial role in regulating the sleep-wake cycle. During the night, the production of melatonin increases, helping you to fall asleep. As daylight approaches, the secretion of melatonin decreases, allowing you to awaken feeling rested and refreshed.

Your melatonin production is regulated by the body’s internal clock, known as the suprachiasmatic nucleus (SCN). Located in the hypothalamus, the SCN responds to light exposure and adjusts the production of melatonin accordingly. Exposure to bright light at night can disrupt this process, making it difficult for you to fall asleep and maintain healthy sleep patterns.

Circadian Rhythm

A key element in understanding the function of melatonin is the circadian rhythm, the body’s internal 24-hour clock that regulates various physiological processes, including the sleep-wake cycle. Melatonin plays an essential role in maintaining your circadian rhythm by responding to the daily changes in light-dark cycles.

During the day, when light levels are high, melatonin production is suppressed. As darkness falls, your melatonin levels begin to rise, signaling to your body that it’s time to prepare for sleep. In the early morning hours, melatonin production decreases, helping you to awaken and getting your body ready for the day ahead.

By supporting the synchronization of your circadian rhythm, melatonin enables a healthy sleep pattern and ensures that you get enough rest to maintain your overall well-being.

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Health Benefits of Melatonin

Melatonin, a hormone naturally produced by your body, plays an essential role in regulating your sleep-wake cycle. Apart from its widely known function in promoting better sleep, you might be surprised to learn that melatonin offers various other health benefits.

As a powerful antioxidant, melatonin helps neutralize harmful free radicals, thereby maintaining cellular health. Your body tends to have lower melatonin levels as you age, which can contribute to common age-related insomnia issues. However, it’s believed that maintaining healthy melatonin levels may help alleviate this problem.

Melatonin also has the potential to improve your eye health. It aids in eye function by reducing oxidative stress, controlling cellular function, and preventing cellular atrophy. These actions can all help to support your overall ocular health as you get older.

One of the lesser-known benefits of melatonin is its positive effect on heart health. It may help reduce blood pressure, provide relief for anxiety, and even improve your mood. Research suggests that melatonin can help mute wake-promoting signals in the brain, which may prevent you from waking up in the middle of the night – a prevalent symptom of insomnia.

Another crucial feature of melatonin is its ability to regulate immune system responses. This hormone can act as an activator or inhibitor for anti-inflammatory and other immune processes, which play essential roles in your body’s overall health. Additionally, melatonin’s potent antioxidant capacity enables it to remove oxidative stress from inflamed tissues, further supporting your immune system.

In summary, melatonin offers various benefits to your health beyond just sleep regulation. By maintaining optimal melatonin levels, you can potentially enhance your eye health, heart health, immune system, and overall well-being.

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Melatonin Supplements

Melatonin supplements can offer significant benefits for individuals with certain conditions by effectively treating their sleep problems. As a powerful antioxidant, melatonin increases antioxidant enzymes in the body that maintain health on a cellular level. It also neutralizes reactive oxygen and nitrogen species, making them less harmful.

When you take melatonin as a supplement, it may help synchronize your sleep-wake cycles (circadian rhythms), particularly in people with insomnia. While the data does not support using melatonin as a treatment for insomnia, it can still help with specific sleep-related conditions like jet lag, according to research.

In addition to sleep support, melatonin supplements can help ease anxiety symptoms. Since melatonin relaxes your body in preparation for sleep, it also helps with anxiety by getting your brain ready for rest.

To make the most of melatonin supplements, it’s crucial to follow the recommended dosage guidelines. The proper dosage varies depending on individual needs, age, and the condition being addressed. It is advisable to consult a healthcare professional before starting any melatonin supplement regimen to ensure the appropriate dosage for your specific needs.

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Side Effects and Interactions

Melatonin supplements are generally considered safe for short-term use, but they may cause some side effects. You should be aware of these potential side effects, as well as interactions with other substances, to ensure you use melatonin safely.

Common side effects of melatonin include nausea, dizziness, and headaches. If you experience these symptoms, you may want to consult your healthcare provider to determine if melatonin is the appropriate treatment option for you.

In rare cases, melatonin may cause an allergic reaction, which could manifest as itching, hives, or difficulty breathing. If you suspect an allergic reaction, discontinue melatonin use and seek immediate medical attention.

It is essential to note that melatonin may interact with other medications or substances. For example, it may increase the risk of seizures in those with seizure disorders or cause high blood pressure when combined with specific medications. Be sure to discuss any existing health conditions or medication use with your healthcare provider before starting melatonin.

One crucial interaction to be aware of is the combination of melatonin with alcohol. Combining melatonin with alcohol can lead to excessive drowsiness and impaired cognitive function. For your safety, avoid consuming alcohol while taking melatonin.

As with any supplement, it is important to discuss your specific needs and potential risks with a healthcare provider before incorporating melatonin into your routine. By staying informed and monitoring your body’s response, you can safely reap the health benefits of melatonin.

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Sleep Quality and Issues

Melatonin, a hormone that regulates your sleep-wake cycle, plays a significant role in maintaining healthy sleep. For many individuals, using melatonin as a sleep aid can improve sleep quality and help manage sleep issues, leading to more restful nights and better overall sleep hygiene.

Poor sleep quality may be caused by a variety of factors, including an irregular circadian rhythm, stress, or lifestyle habits. By addressing these issues and incorporating melatonin, you can support your body’s natural sleep processes. Melatonin supplements can particularly help those who struggle with falling asleep or staying asleep through the night link to Sleep Foundation.

In addition to general sleep quality, melatonin has shown to provide benefits for specific sleep issues such as jet lag and Non-24-hour sleep-wake rhythm disorder link to Sleep Doctor. As a result, incorporating melatonin can aid in maintaining a balanced circadian rhythm and support your sleep hygiene for a refreshed, more focused day.

However, it’s essential to be mindful of the potential side effects, including drowsiness and daytime grogginess, as well as possible drug interactions link to Sleep Foundation. It’s always a good idea to consult your healthcare professional before adding a new supplement to your regimen.

To best support your sleep quality and address sleep issues, it is crucial to combine melatonin supplements with healthy sleep hygiene practices. This may include:

  • Establishing a consistent sleep schedule
  • Creating a relaxing bedtime routine
  • Making your sleep environment comfortable and conducive to rest
  • Reducing exposure to screens and bright lights before bedtime
  • Limiting caffeine and alcohol consumption close to bedtime

By incorporating these habits along with melatonin supplements, you can work towards better sleep quality and a more balanced daily routine.

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Role in Age-Related Disorders

Melatonin, a hormone secreted by the pineal gland, plays a crucial role in regulating your sleep-wake cycle. With age, the production of melatonin declines, which may contribute to age-related disorders and sleep disturbances. In this section, you will learn about the potential benefits of melatonin in managing age-related disorders such as dementia and autism. Remember to consult with your healthcare provider before starting any form of supplementation.

Dementia is a term used to describe a decline in cognitive ability severe enough to interfere with daily life. One contributing factor to dementia could be the decrease in melatonin levels as you age. Research suggests that melatonin exhibits immunomodulatory properties, which play a role in aging and can help protect against neurodegeneration. Conditions like Alzheimer’s disease and Parkinson’s disease are marked by neurodegenerative processes.

Autism Spectrum Disorder (ASD) is a developmental disorder that affects communication and social interaction. Studies have shown that individuals with autism often experience sleep disturbances, which may be associated with abnormal melatonin secretion. Supplementing with melatonin has been demonstrated to improve sleep patterns in people with autism. Regular and restorative sleep is essential for optimal neurological functioning and overall well-being.

While melatonin supplementation may show promise in managing age-related disorders, more research is needed to better understand its long-term impact. Always seek professional medical advice before incorporating any new supplements into your routine. Melatonin can be a useful aid in addressing sleep issues and improving overall health, especially in the context of age-related disorders like dementia and autism.

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Eye Health

Melatonin is a hormone that your body produces at night, which helps regulate your sleep-wake cycle. However, its benefits extend beyond sleep regulation and can positively impact your eye health.

Exposure to blue light from digital screens and other artificial light sources can disrupt your natural melatonin production. This disruption may lead to difficulties in falling asleep and maintaining a healthy sleep cycle. Yet, melatonin’s antioxidant properties may also help protect your eyes against the harmful effects of blue light, thereby preventing potential damage to your eye structures and vision.

One of the critical aspects of eye health where melatonin plays a role is in the prevention and management of glaucoma. Glaucoma is a group of eye conditions that damage the optic nerve, often resulting from increased intraocular pressure. Research has found that melatonin’s cell protection properties could help treat glaucoma by reducing oxidative stress and inflammation that contribute to optic nerve damage.

Moreover, melatonin has been linked to reducing symptoms associated with age-related macular degeneration (AMD), a leading cause of vision loss in older adults. AMD occurs when the central portion of the retina (the macula) deteriorates, leading to disrupted central vision. The powerful antioxidant properties of melatonin may contribute to preventing the development and progression of AMD by protecting the delicate retinal cells from degeneration.

In summary, maintaining healthy melatonin levels is essential not only for a restful sleep but also for preserving your eye health. The hormone’s antioxidant properties can help protect your eyes from the adverse effects of blue light exposure, glaucoma, and age-related macular degeneration.

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Immune System and Inflammation

Melatonin has been shown to play a crucial role in boosting your immune system and combating inflammation. It’s a versatile hormone that not only regulates your sleep-wake cycle but also has other significant benefits for your overall health.

One of the ways melatonin helps your immune system is by regulating the production of cytokines. Cytokines are proteins that act as messengers between cells and play a vital role in immune response. By modulating cytokine production, melatonin can help to maintain the delicate balance required for optimal immune function.

Additionally, melatonin acts as a powerful antioxidant, neutralizing harmful free radicals that cause oxidative stress in your body. Oxidative stress can lead to chronic inflammation, which is associated with a wide range of health problems, including autoimmune disorders and chronic diseases. By reducing oxidative stress, melatonin can help alleviate chronic inflammation and improve your overall health.

It’s also worth noting that melatonin can support immune health by promoting a good night’s sleep. Sleep deprivation can weaken your immune system, making you more susceptible to illnesses and infections. By helping you get sufficient rest, melatonin can contribute to a stronger immune system.

Remember, though, that you should always consult your healthcare professional before supplementing with melatonin, especially if you’re already taking medications or have underlying health conditions. They’ll be able to guide you on the appropriate dosage and ensure that it’s safe for you. By considering melatonin as part of your healthy lifestyle, you’re taking steps to support your immune system and reduce inflammation in your body.

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Cancer and Melatonin

Melatonin, a hormonal substance produced by your body, has numerous health benefits and has been studied for its potential role in cancer prevention and treatment. In cancer cells, melatonin appears to have direct anticancer actions, as well as its ability to stimulate your body’s own immune system to fight against cancer cells more effectively 1.

Several studies have shown that melatonin can help protect blood cell precursors from the toxic effects of chemotherapy and radiotherapy, making it a potential adjuvant therapy alongside conventional cancer treatments 2. The ability to augment your body’s natural killer T-cell activity is another mechanism by which melatonin might contribute to cancer prevention and treatment 3.

A systematic review of randomized controlled trials and meta-analysis suggested that melatonin could have a positive impact on reducing cancer-related symptoms and increasing overall survival rates in some cases 4. While these findings are promising, they should be interpreted with caution, as more research is needed to fully understand the extent to which melatonin can be beneficial in cancer treatment.

In summary, melatonin has shown potential in cancer prevention and treatment. It appears to have direct anticancer effects, stimulate your immune system, and protect against the adverse effects of conventional cancer treatments. However, further research is necessary to understand the full scope and limitations of melatonin in this context.

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Footnotes

  1. Melatonin in Cancer Treatment: Current Knowledge and Future …

  2. Melatonin in Cancer Prevention and Treatment – Verywell Health

  3. Melatonin for cancer patients: Is it safe? – MD Anderson Cancer Center

  4. High Dose Melatonin Therapy – An Ideal Adjuvant Anti-cancer Therapy

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Natural Sources of Melatonin

Melatonin is a hormone produced by your pineal gland that helps regulate sleep and wake cycles. It can also be found in some foods or taken as a dietary supplement. Incorporating natural sources of melatonin into your diet can help improve your sleep quality and overall health.

Fruits and vegetables are rich in essential nutrients and can also provide some melatonin. Some fruits that contain melatonin include cherries, bananas, and grapes. Additionally, corn, tomatoes, and olives are examples of vegetables that provide melatonin. Consuming a varied diet rich in fruits and vegetables can help ensure adequate melatonin levels in your body.

Amino acids are the building blocks of proteins and play a crucial role in many physiological processes, including melatonin production. The amino acid tryptophan is a precursor of serotonin, which in turn, is used to produce melatonin. Tryptophan can be found in foods such as eggs, dairy products, nuts, and seeds. Including these foods in your diet may help support melatonin production.

Serotonin is an essential neurotransmitter involved in many aspects of brain function, including mood regulation and sleep. As mentioned earlier, serotonin is a precursor to melatonin, meaning that increasing serotonin levels can boost melatonin production. Foods high in tryptophan, omega-3 fatty acids, and vitamin B6 can help increase serotonin levels, which may ultimately contribute to maintaining healthy melatonin levels in your body.

For those who want an extra boost, melatonin is available as a dietary supplement. It can be found in various forms, such as capsules, tablets, and even gummies. However, it’s essential to consult with your healthcare provider before taking melatonin supplements to ensure the proper dosage and to avoid potential interactions with other medications you may be taking.

In conclusion, incorporating a variety of fruits, vegetables, and other foods rich in melatonin precursors into your diet can help support healthy melatonin levels and ultimately improve your sleep quality. Don’t forget to also maintain a consistent sleep schedule and create a relaxing bedtime routine to optimize your sleep and overall well-being.

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Inducing Melatonin Production

To help your body naturally produce more melatonin, it’s essential to create the right environment and adopt healthy lifestyle habits. Here are some strategies to consider:

Try to limit your exposure to light in the evening. This can be achieved by dimming the lights, reducing screen time, and using blackout curtains to block out external light sources. Keep in mind that bright light exposure during daytime can help regulate your circadian rhythm, so it’s important to balance your exposure to light throughout the day.

Regulate your body weight and maintain a healthy metabolism. A well-balanced diet, regular exercise, and good sleep hygiene can all contribute to a healthy body weight and improved melatonin production. Remember that darkness is essential for melatonin production.

Keep your caffeine consumption in check. Consuming caffeinated beverages, such as coffee and energy drinks, can disrupt melatonin production, especially when consumed close to bedtime. It’s best to avoid caffeine several hours before going to sleep to prevent interference with melatonin secretion.

Establish a consistent sleep schedule by going to sleep and waking up at the same time each day, even on weekends. This helps regulate your body’s internal clock and can positively affect melatonin production.

By implementing these measures, you can create the ideal conditions for your body to produce melatonin, leading to improved sleep quality and overall well-being.

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Managing Sleep Disturbances

Melatonin is a hormone produced by your pineal gland, playing a crucial role in regulating your sleep-wake cycle. It can be helpful in managing sleep disturbances, such as jet lag and drowsiness.

For jet lag, your body’s internal clock becomes misaligned due to rapid travel across multiple time zones. Taking melatonin supplements can help your body adjust to the new time zone and reduce the symptoms of jet lag. It’s recommended to take melatonin close to the target bedtime at your destination, starting a few days before you travel and continuing for a couple of days upon arrival. Remember that it might not work for everyone, and it’s important to consult with your healthcare provider before using melatonin for jet lag.

Drowsiness, which may stem from a variety of causes, can also be managed with melatonin. If you’re struggling to fall asleep or stay asleep, melatonin might be a solution. However, it’s essential to note that melatonin is not a one-size-fits-all cure for insomnia. Research suggests that taking melatonin for short periods of time can be more effective than a placebo for sleep onset insomnia, which is the difficulty in initially falling asleep 1.

When considering melatonin to improve your sleep, it’s important to start with a low dosage and gradually increase if needed. Dosages may vary among individuals, and it’s always best to consult with a healthcare professional before incorporating melatonin into your routine. Remember to maintain good sleep hygiene to further support melatonin’s effectiveness.

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Footnotes

  1. Cleveland Clinic: Can Melatonin Really Help You Sleep Better?

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Other Uses of Melatonin

Besides its well-known role in promoting good sleep, melatonin serves several other functions in your body. It can provide benefits related to your overall wellbeing and alleviate a variety of health issues.

Melatonin has been shown to help reduce pain and inflammation in conditions like atopic dermatitis or GERD (gastroesophageal reflux disease). These benefits are in part due to melatonin’s ability to regulate cortisol levels, which helps manage stress responses in your body.

Another noteworthy benefit of melatonin is its function as a powerful antioxidant. This means it can help protect your body from the harmful effects of free radicals, which are molecules that can damage cells and contribute to aging. Incorporating melatonin into your routine may improve your overall health and slow down the aging process.

In some cases, melatonin has been found to assist in managing diabetes, by helping to regulate blood sugar levels. However, if you are considering using melatonin for this purpose, it’s crucial to consult a healthcare professional before making any changes to your regimen.

Finally, recent research suggests that melatonin may share some properties with cannabidiol (CBD), a compound derived from the cannabis plant. Both CBD and melatonin have been found to alleviate anxiety, reduce inflammation, and promote sleep. While more research is needed to establish the exact relationship between these two compounds, it is clear that melatonin has a wide range of uses beyond regulating sleep cycles.

In conclusion, melatonin offers various benefits beyond promoting quality sleep. It supports your overall wellbeing, from managing pain to acting as a powerful antioxidant. However, before using melatonin to address specific health issues, it’s crucial to consult a healthcare professional to ensure the proper approach and dosage for your needs.

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Alternatives to Melatonin

If you’re looking for alternatives to melatonin to improve your sleep, you have a few options to consider. One popular choice is herbal tea. Drinking a warm cup of herbal tea before bedtime can help you relax and ease into a restful night’s sleep. Some of the best teas for sleep include chamomile, valerian root, and passionflower1.

In addition to herbal teas, you can also try adjusting your bedtime habits to facilitate better sleep. Limiting your exposure to blue light from screens in the evening can help regulate your natural melatonin levels2. To achieve this, make a conscious effort to avoid devices such as smartphones, tablets, and computers for at least an hour before you plan to sleep.

Another factor that can impact your sleep is your environment. Make sure your bedroom is cool, dark, and quiet. Investing in blackout curtains and using a white noise machine can make a significant difference. Also, ensure that your mattress and pillows are comfortable and supportive.

Water might seem like an odd suggestion, but staying hydrated throughout the day can improve your overall health and may contribute to better sleep3. Make sure to drink plenty of water, but avoid consuming large amounts shortly before bedtime, as this can lead to unwanted awakenings.

Lastly, stay informed with the latest news and research on sleep and be open to trying new strategies. As sleep science evolves, more alternatives to melatonin may become available4.

Remember, finding the right sleep solution may take some trial and error. Don’t be afraid to experiment with different strategies to determine what works best for you.

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Footnotes

  1. https://pzizz.com/blog/articles/substitutes-for-melatonin/

  2. https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side

  3. https://www.sleepfoundation.org/sleep-hygiene

  4. https://honehealth.com/edge/health/melatonin-alternatives/

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Conclusion

Melatonin is a hormone known for promoting sleep and regulating sleep patterns. Its use as a supplement has been widely studied, with many benefits being attributed to its consumption. As you consider incorporating melatonin into your daily routine, it’s essential to be aware of these potential advantages and how they can impact your overall well-being.

One of the most significant benefits of melatonin is its ability to help with sleep regulation. In addition to supporting a healthy sleep cycle, melatonin can also alleviate symptoms of insomnia, allowing you to get more peaceful, restful nights.

Additionally, other health benefits have been associated with melatonin. These include promoting eye health, aiding in the treatment of acid reflux diseases, and potentially providing support for the immune system.

Although melatonin offers several health benefits, understanding the proper dosage and forms is crucial for safe, effective use. It’s essential to consult with a healthcare professional before beginning any melatonin supplementation, as individual needs may vary. The appropriate dosage largely depends on factors such as age, lifestyle, and specific sleep concerns.

To sum up, melatonin can provide various health benefits beyond just sleep regulation. With proper guidance and usage, it may be an effective tool to help improve your overall well-being and daily life. Remember to always consult with a healthcare professional before starting any new supplement to ensure safe and proper usage.

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Frequently Asked Questions

What are the potential long-term effects of melatonin use?

While melatonin is generally considered safe for short-term use, the potential long-term effects have not been extensively studied. Some reports suggest that extended use of melatonin might lead to mild side effects, such as drowsiness, headache, dizziness, or irritability. Always consult with your healthcare provider before using melatonin supplements over an extended period.

Does melatonin contribute to weight gain?

There is no substantial evidence that melatonin directly leads to weight gain. However, since melatonin can have an impact on your sleep patterns, changes in sleep quality may affect your weight over time. If you’re concerned about weight gain, it’s essential to maintain a balanced diet and an active lifestyle while using melatonin supplements.

What is the recommended dosage for melatonin supplements?

The recommended dosage for melatonin supplements varies depending on factors such as age, weight, and the specific sleep issue being addressed. Generally, a dosage range between 0.5mg and 5mg is considered safe for adults. However, it’s crucial to consult with a healthcare professional before taking melatonin to determine the appropriate dosage for your individual needs. More information on melatonin dosage can be found at the Sleep Foundation.

Are there any risks associated with melatonin use in the elderly?

Melatonin can be helpful in improving sleep quality for older adults who experience difficulty in falling or staying asleep. However, it’s vital to consult with a healthcare provider before using melatonin supplements, as older individuals may have a heightened risk of side effects or drug interactions with other medications they’re taking.

Can melatonin be considered addictive?

Melatonin is not considered addictive, as it is a naturally occurring hormone produced by the body. However, it is essential to use melatonin supplements responsibly and under the guidance of a healthcare professional to avoid potential issues related to inappropriate use or dosage.

How does melatonin impact brain health?

Melatonin plays a role in promoting brain health as it is involved in regulating sleep-wake cycles, and quality sleep is crucial for optimal brain function. Moreover, research has shown that melatonin may also help protect against neurodegeneration, which can be present in conditions such as Alzheimer’s and Parkinson’s disease. You can read more about melatonin’s role in brain health at the Cleveland Clinic.


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